No. Otto is one of the most unique, fun, and recognizable mascots in all of college sports. Getting rid of him or the orange name/identity of Syracuse would be a hideously bad idea. There is a school of thought that says the mascot is supposed to be scary, intimidating, aggressive, or whatever. Please. I'm sure the 300 lb linemen and 6'10" basketball players Syracuse plays against would be totally cowed if we had a generic "wildcat" stuffed animal with fangs. Otto is absolutely perfect for a mascot.
If you insist it has to be a strike-fear-in-the-hearts of the opponent mascot, then I will settle for nothing short of changing the mascot to a nuclear bomb. Not a stuffed animal, but an actual, live, armed nuclear bomb that the cheerleaders (or Dome Eddie) rolls around the dome on a dolly.