Who knows if it will even happen but in a perfect world, it would have been held in Brooklyn or Newark this year and MSG next year. With the possible exception of Buffalo, the NYC area is where we are going to have the strongest turnout of Syracuse fans.
I bet that the reason they went with DC is that they are going to go with MSG next year, and they didn't want to have the Eastern Regional in the NYC area two years in a row.
2009 Eastern regional: Boston
2010 Eastern regional: Syracuse
2011 Eastern regional: Boston
2012 Eastern regional: Washington DC
2013 Eastern regional: TBD (all the other sites have been announced, MSG?)
I would think the 2014 venue will almost surely be in North Carolina, which means the earliest we might see an Eastern Regional in Syracuse is 2015. We should have hundreds of new hotels built by then.