Playing ND in the Meadowlands or in South Bend isn't big, playing PSU in Happy Valley isn't big, playing LSU in Death Valley won't be a big deal in a couple years (Honestly, I like that both Clemson and LSU claim the name. It is definitely one of the coolest, if not the coolest, of nicknames for a home field). We play FSU, is that big enough? If the Orange get rolling again, playing in the Dome is a tough place to play.
As for not playing Michigan, PSU, Miami, Alabama, Auburn and ND annually, Clemson's schedule doesn't come close, not really a comment with meaning. Tough venues are all over.