Syracuse is 6-1 against Top 50 teams at home (.857 winning percentage).
Wake Forest is 1-2 against Top 50 teams at home (.333 winning percentage).
Syracuse is 0-6 against Top 50 teams on the road. That's obviously bad.
Wake Forest is 0-7 against Top 50 teams on the road. Also bad.
Also consider: Syracuse has played #3 UNC and #4 Louisville on the road. The highest ranked team Wake has played on the road is #12 Florida State.
Advantage: Syracuse
Yes, obviously. A win is a win. Has the committee historically punished winning teams for buzzer beaters?
And Wake lost all three. Syracuse played South Carolina and Wisconsin away from home. Does Wake get advantage over Syracuse because they lost three games against quality opponents on the road compared to Syracuse's two? Does the committee reward teams for losing games? From what I've seen, the committee cares more about who you beat than who you lost to.
Charleston, Richmond, and Greensboro?
Wake Forest best true road victory: vs. #91 Richmond
Syracuse best true road victory: vs. #61 Clemson
Wake's rankings are the only thing they have going for them now. They are good because Wake has avoided bad losses. Which is nice. But based on the evidence we have available to us from the selection committee's choices over the last two seasons, the committee will reward teams much more for winning quality games than they they will for avoiding bad losses.
The choice is obvious. But it ain't for Wake Forest.