Louisville traditionally underperforms as a 4 seed getting knocked out either in the first round (like last year) or the second round (by the 5 seed). But as a 3 seed they usually get to the Sweet 16 and beyond. It will be interesting to see where they are seeded now.
Don't see a 3 seeded LV losing to the 14 (although it can and has happened). Certainly see them losing in the 2nd, but I could also see them getting to the 2nd weekend (and not much farther).