Okay, WMU guy here. I'm straight-up, I pick Syracuse to win -- but I would by no means shocked if WMU win (which Vegas odds reflect).
About the WMU vs MSU game. MSU has always had a powerful D in any relatively decent year or better. This year, in terms of yards given up: They're #3. They've given up 216 yards on average. How many did WMU get? 354 yards. Which is more than most B1G teams will get against them. MSU held Tulsa to 80 yards. Tulsa scored 21 points against Oklahoma State in the 1st half.
WMU has a high powered offense -- by P5 standards. You'd be fooling yourself otherwise if not thinking that. WMU should have scored more based on that -- missed 2 FGs (one a chip shot), and threw an INT by our good QB in the end-zone.
WMU has a high powered offense for P5, but...
WMU has a bad-but-improving D for G5
That's your saving grace against an upset by a team lead by a former SU coach going into the Dome.
WMU gave up over 300 yards to FCS team -- granted an expected decent one with a 5th year SR QB who's among the better in FCS -- but still. Bad.
And despite holding Georgia State to 10, who scored MANY on Tennessee, they still got 336 or so yards. So it wasn't like they couldn't move the ball. We forced turnovers to keep their score low, while we scored AT WILL. Our D improved, but it was helped by keeping them out of rhythm, but they helped themselves on that with penalties, traveling all the way up to Michigan, from Georgia. WMU's D is improving. And MSU's Offense & it's potential isn't as bad as you think. They had 400 yards on AZ-State, despite scoring just 7pts (3 missed FGs too; would have won, but still too few points for yards gained).
In the end, Babers is a good coach. SU is NOT in a typical situation to "bounce back" after a bad game. SU's chances would be Better if they played WMU right after that bad Maryland game -- not after that + Clemson who's been 'rival' of sorts the last two years, to get shelacked. Babers will have him ready the best he can.
I expect Syracuse to get their O going like MSU did -- and to put up about 34-40 pts. I expect the noise & heat of the Dome to keep WMU at bay, and SU wins the turnover battle, which makes them pull out the win by 10-17 pts.